This quatrain appears to describe a major Middle Eastern transformation centered on Iran. The "chief of Persia" who will "replenish the great Chaldea" suggests a new Iranian leader who emerges after Western naval forces ("trireme fleet") confront the Islamic Republic. Here, "Chaldea" represents Israel - either through the historical connection of Jewish exile to Babylon, or as a coded reference to the modern Jewish state.

The geographic scope - "from Parthia and Media and the Cyclades to Pillage" - encompasses the entire region from ancient Persia through the Eastern Mediterranean, including the former Greek territories that now comprise Israel and surrounding areas. The word "pillage" implies the dismantling of the current Islamic system. The quatrain concludes with these Western forces withdrawing to "rest for a long time at the great Ionian port," suggesting a permanent transformation has been achieved.

In this reading, Nostradamus foresaw the end of Iran's Islamic Republic through Western intervention, followed by a new Persian leadership that would "replenish" Israel - dramatically reversing current Iranian policy from hostility to support. This would represent a return to pre-1979 relations when Iran and Israel were allies. The emphasis on "Islamic People" rather than simply "Persians" specifically highlights the religious nature of the current regime that would be replaced, making way for a secular Persian leadership that restores the ancient connection between Persia and the Jewish people.